Current Status Of Bone Morphogenetic Protein-2
نویسندگان
چکیده
منابع مشابه
Bone morphogenetic protein-2 stimulates Runx2 acetylation.
Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway. Genetic analysis has revealed that Runx2 is degraded through a Smurf-mediated ubiquitination pathway, and its activity is inhibited by HDAC4. Here, we demonstrate the molecular link between Smurf, ...
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ژورنال
عنوان ژورنال: Osteoporosis and Sarcopenia
سال: 2018
ISSN: 2405-5255
DOI: 10.1016/j.afos.2018.11.034